| abstract |
The invention relates to substituted carbazole derivatives, to their pharmaceutically acceptable salts, solvated forms, to processes for their preparation, to the pharmaceutical compositions containing them and to their use in medicine for lowering the level of estrogens and / or androgens. The compounds have the formula wherein R1 and R4 independently represent a hydrogen atom or a C1-6 alkyl group, all substituents r2 may be the same or different and denote an electron acceptor group all the substituents r3 may be the same or different and denote an electron acceptor group, R 5 is a group of the formula R 6 is a halogen atom, a C 1-6 alkyl group or a C 1-6 alkoxy group; m has a value of 0 or an integer of 1 to 4; n 0 or an integer from 1 to 3 and p is 0, 1 or 2. |