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filingDate 1986-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1986-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BE-904957-A
titleOfInvention PROCESS FOR THE PREPARATION OF 2-HALO-NICERGOLIN DERIVATIVES AND THEIR ADDITION SALTS WITH ACIDS AND NEW 2-HALONICERGOLINS, COMPOSITIONS COMPRISING 2-HALONICERGOLINS AND PROCESS FOR THE PREPARATION THEREOF.
abstract Process which consists in esterifying a 2-halo-1-methyl-lumilysergol of formula in which X represents a chlorine, bromine or iodine atom or its addition salt with an acid and, optionally converting the derivative of 2 -halonicergoline thus obtained in an addition salt with an acid. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic action, an alpha-adrenergic blocking action and an action of calcium antagonism. Pharmaceutical applications.
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