http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BE-904458-A

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-23
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-23
filingDate 1986-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19215676085896372593abdee22c1f47
publicationDate 1986-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BE-904458-A
titleOfInvention NOVEL PROCESS FOR THE PREPARATION OF (D-TRP6) -LHRH AND BENZHYDRYLAMINIC RESIN AND PEPTIDE COMPLEX.
abstract Process for the preparation of (D-Trp6) -LHRH in solid phase on a benzhydrylaminic resin, characterized in that the protected amino acids are introduced onto the polymer support with double condensation, in that the hydroxyl radical of the serine is protected thanks to a benzyl group, the hydroxyl radical of tyrosine thanks to a 2,6-dichlorobenzyl group, the guanidine group of arginine thanks to a tosyl group, the indole nucleus of L- and D-tryptophan thanks to a formyl group and l nitrogen-TT of the imidazolic nucleus of histidine thanks to a benzyloxymethyl group, and in that the final removal of the protection of the side chains and the separation of the peptide from the support are carried out thanks to a treatment subsequent to the hydrofluoric acid at low and high concentration.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1343808-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7122628-B2
priorityDate 1985-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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