| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d709e3167fa2f99a1803c9cfeb0aca63 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12R2001-15 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-205 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 |
| filingDate |
1982-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21b1ea94c65fcc0cea526ed0bbe6ce68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7f07976b5e69aadfa952d49f7f5def5 |
| publicationDate |
1983-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BE-895374-A |
| titleOfInvention |
NEW ANTITUMOR AGENT OBTAINED BY MICROBIAL STEREOSELECTIVE REDUCTION OF 4-DEMETHOXYDAUNORUBICINE |
| abstract |
Stereoselective redn. of 4-demethoxydaunorubicin (I) to give only the single 13-dihydro isomer (II) comprises cultivating a new mutant of the species Streptomyces peucetius subs. aureus (strain 15 87 F.I.), Mycobacterium fortuitum or Croynebacterium mediolanum in presence of (I) under aerobic conditions in an aq. nutrient medium. Pref. cultivation is for 3-8 days at 25-27 esp. 29, deg.C. The new strain M87 F.I. (DSM 2444) is made by treating a parent strain with nitrosoguanidine. (II), described as a new cpd., is an antitumour agent about as actiVe as 4-demethoxydaunorubicin. |
| priorityDate |
1982-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |