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publicationDate 2020-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BE-1027147-A1
titleOfInvention BIOMARKER OF PNEUMOCONIOSIS OF COAL WORKERS AND ITS APPLICATION
abstract The invention relates to the detection of a biologically associated biomarker of pneumoconiosis in coal workers. Further, the present invention discloses a coal worker pneumoconiosis biomarker and its application, and in particular, an application of an article for detecting an expression level of a biomarker in the preparation of a reagent for indicating the coalworker pneumoconiosis in an object, the biomarker being miR-138 and the reagent being used in a method comprising the steps of: detecting a level of expression of miR-138 in the object, comparing the level of expression of miR-138 in the object at a reference level of expression of miR-138, and indicate the pneumoconiosis of coal workers in the object based on the comparison, the level of expression of miR-138 in the object being lower than the reference level of expression of miR-138 to indicate the pneumoconiosis of coal workers in the object. The present invention has identified the link between coalworker pneumoconiosis and the reduced expression level of miR-138, can be used as a specific biomarker for coalworker pneumoconiosis, and therefore has important clinical significance.
priorityDate 2019-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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