| abstract |
Gem-difluoro compounds of the formula: wherein: R1 may be hydrogen or an acyl or substituted acyl group; R2 represents hydrogen or a lower alkyl, substituted lower alkyl, nitro, halogen, methylenedioxy, trifluoromethyl or OR 'group; Y represents oxygen, sulfur or a group NR "; R3 represents hydrogen, a lower alkyl group, substituted lower alkyl, phenyl, substituted aryl or a metal chosen from the group comprising sodium, potassium, calcium, magnesium, zinc and aluminum; R 'and R "represent hydrogen or a lower alkyl, substituted lower alkyl, phenyl or substituted aryl group, their preparation and their uses as anti-inflammatory and antirheumatic agents. |