http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BE-1007297-A3

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filingDate 1993-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1995-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35bb739769bfd24bf20e405e96c3b812
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publicationDate 1995-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BE-1007297-A3
titleOfInvention OPTICAL METHOD FOR THE PREPARATION OF ACTIVE alcohols and esters, alcohols and esters APPLIED AND WILLING TO SUCH METHODS.
abstract The invention relates to a process for the preparation of optically active N-substituted-3-pyrrolidinol of the general formula (1) of the formula sheet, wherein R is a linear, cyclic or branched alkyl, alkenyl, aryl, alkaryl or aralkyl group optionally substituted with one or more halogen atoms or wherein R = OR 2 wherein R 2 may have the same meaning as described above for R, via enantioselective enzymatic hydrolysis of a corresponding N-substituted-3-acyloxy-pyrrolidine of the general formula (2) of the formula sheet wherein R is as defined above and wherein R 1 represents an acid moiety, for example a linear, cyclic or branched alkyl, alkenyl, aryl-alkaryl or aralkyl group, optionally substituted with one or more halogen atoms; a process for the preparation of an optically active N-substituted-3-acyloxy-pyrrolidine compound, wherein a mixture of the enantiomers of the corresponding N-substituted-3-pyrrolidinol is subjected to an enzymatic, enantioselective esterification in the presence of a suitable enzymatic esterifying agent using an enzyme
priorityDate 1993-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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