| titleOfInvention |
Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as KRAS G12C inhibitors for treating lung, pancreatic or colorectal cancer |
| abstract |
BENZISOTHIAZOLE, ISOTHIAZOLO[3,4-BIPYRIDINE, QUINAZOLINE, nPHTHALAZINE, PYRIDO[2,3-DIPYRIDAZINE AND PYRIDO[2,3-DIPYRIMIDINE nDERIVATIVES AS KRAS G12C INHIBITORS FOR TREATING LUNG, PANCREATIC nOR COLORECTAL CANCER nABSTRACT nProvided herein are KRAS G12C inhibitors, composition of the same and methods of using the nsame. These inhibitors are useful for treating a number of disorders, including pancreatic, ncolorectal, and lung cancers. |