| abstract |
Imipridones has been found to selectively modulate Class A G protein-coupled receptors n(GPCRs), such as the D2-like subfamily of dopamine receptors, and to be useful for the n5 treatment of conditions and disorders in need of such modulation, such as cancers, psychiatric ndisorders, and bacterial infections. In addition, methods of identifying whether a subject having nthese condition, is likely to be responsive to a treatment regimen, such as administration of an nimipridone, are provided. Furthermore, methods of assessing the effectiveness of a treatment nregimen, such as administration of an imipridone, monitoring, or providing a prognosis for a n10 subject with these condition are also provided. n18435876_1 (GHMatters) P44343AU01 28/01/22 |