| abstract |
Documen8-0/I1/2021 nABSTRACT n5'-CYCLO-PHOSPHONATE MODIFIED NUCLEOTIDES n5 Described are 5'-cyclo-phosphonate modified nucleotides, and oligonucleotides, such as ninterference (RNAi) agents, containing 5'-cyclo-phosphonate modified nucleotides. The nRNAi agents having either double-stranded or single-stranded oligonucleotides described nherein comprising 5'cyclo-phosphonate modified nucleotides are useful in modulating gene nexpression as well as therapeutic, diagnostic, target validation, and genomic discovery n10 applications. The RNAi agents and single-stranded antisense oligonucleotides comprising n5'-cyclo-phosphonate modified nucleotides are useful in the treatment of diseases or nconditions that respond to inhibition of gene expression or activity in a cell, tissue, or norganism. |