| abstract |
Provided herein are pharmaceutically acceptable aqueous solution comprising a neuroactive nsteroid, a sulfobutyl ether beta cyclodextrin and a buffer; wherein: the solution is a stable solution nbetween a pH of about 3 and about 9, e.g., at room temperature, for at least 1, 2, 3, 4 weeks; 1, 2, 3, 4, 5, n6, 7, 8, 9, 10, 11, 12 months; 1, 2, 3 years or more; the buffer is present at a concentration of at least 0.1 nmM; or the solution remains substantially free of impurities (e.g., the solution is substantially free of nimpurities at room temperature for at least 1, 2, 3, 4 weeks; 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 months; 1, 2, n3 years or more). |