abstract |
In certain aspects, the present invention provides compositions and methods for modulating n(promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or nneuronal tissue. The present invention also provides methods of screening compounds that nmodulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and nmethods provided herein are useful in treating diseases associated with abnormal activity of an nActRIIB protein and/or an ActRIIB ligand. |