abstract |
The disclosure features novel lipids and compositions involving the same. Nanoparticle ncompositions include a novel lipid as well as additional lipids such as phospholipids, structural nlipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or nprophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to nmammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression. |