abstract |
Disclosed herein is a recombinant nucleic acid, comprising: a mitochondrial targeting nsequence; a mitochondrial protein coding sequence, wherein said mitochondrial protein coding nsequence encodes a polypeptide comprising a mitochondrial protein; and a 3'UTR nucleic acid nsequence. Also disclosed is a pharmaceutical composition comprising the recombinant nucleic acid nand a method of treating Leber's hereditary optic neuropathy (LHON) using the pharmaceutical ncomposition. |