| abstract |
Described herein are phenylsulfonamido-benzofuran derivatives, and pharmaceutically nacceptable salts thereof. Also provided are pharmaceutical compositions, methods, uses, and nkits involving compounds of Formulae (I), (II), (III), (IV), (V), or (VI) for treating and/or npreventing proliferative diseases (e.g. cancers, inflammatory diseases, and autoimmune ndiseases) in a subject. The compounds and pharmaceutical compositions as described herein ninhibit at least one protein of the BCL-2 family in a biological sample or subject to treat and/or nprevent a proliferative disease. In certain embodiments, compounds described herein are nselective inhibitors of MCL-1, a BCL-2 family member protein. nR(R (R )n n0 L7 -0 R21 nO ( O RN -O(R nR4 RZ R nR n(IV) (V) (Vi) |