| abstract |
Disclosed are compounds of formula I, and pharmaceutically acceptable salts thereof nThe compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical ncompositions comprising at least one compound of the invention, and methods involving use nof the compounds and compositions of the invention in the treatment and prevention of ndiseases and conditions characterized by unwanted plasma kallikrein activity. n(R1)" nZ nN N-V n\ R4 n/W H ,X- ' nR2 R3 n'R3a g |