| abstract |
In the present Invention we have synthesized a series of novel Benzothiazole derivatives by nusing sulfa drugs.The Benzothiazole derivatives such as substituted 2-benzylbenzo[d]thiazole-6nsulfonamide were synthesized by a different procedure in which substituted benzyl bromide were nreacted with sodium cyanide to formed substituted benzyl cyanide which were reacted with nsulfuric acid to formed substituted benzyl acetic acid which were reacted with thionyl chloride to nformed substituted benzyl acetyl chloride. These substituted benzyl acetyl chloride were reacted nwith sulfanilamide to form substituted 2-benzyl-N(-4-sulfamoylphenyl)acetamide which were nfurther reacted with Lawessons reagent to formed substituted 2-benzyl-N(-4nsulfamoylphenyl)ethanethioamide. The cyclization of substituted 2-benzyl-N(-4nsulfamoylphenyl)ethanethioamide were prepared in the prensence of Dess-Martin priodinane nwith dichloromethane and then prepared Benzothiazole nucleus. nThe chemical structures of the synthesized compounds were confirmed by means of IR, nH-NMR, Mass spectral. These compounds were screened for anti-inflammatory activity by ncarrageenan induced paw oedema method in rats at a dose of 10 mg/kg body weight. nAmong the tested compounds of benzothiazole derivatives, compounds Rm 2, Rm 3, Rm5 , Rm8 & nRmg exhibited some anti-inflammatory activity but compounds Rmi, Rm 4, Rm6 , Rm8 & Rmio nwere more potent when compared to standard drug Aspirin. |