http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2021104317-A4

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filingDate 2021-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e616c48aa4d8662792acf957f40170b8
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publicationDate 2021-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AU-2021104317-A4
titleOfInvention An Artemether-Loaded Nanostructured Lipid Carrier (NLC) Nanogel Composition and A Method for Formulation of the Artemether-Loaded (NLC) Nanogel
abstract The present disclosure relates to an artemether-loaded nanostructured lipid carrier n(NLC) nanogel composition and a method for formulation of the artemether-loaded (NLC) nnanogel. The method comprises: dissolving an optimized ART concentration of 0.25g in 5% nw/v mixture of solid and liquid lipids at 90 °C; adding an aqueous surfactant phase wherein naqueous phase comprises: Tween-80, sorbitol and aqueous phase at 90°C dropwise under nconstant stirring for a time period; homogenizing a pre-emulsion rapidly and further probe nsonicating the pre-emulsion for a time period; cooling the resultant NLC at room temperature nand freezing, prior to lyophilization; dissolving Carbopol 971P NF (C971P), Prosopis nafricana peel powder (PAPP), and Poloxamer 407 (P407) in a pre-cooled purified water to nobtain a mixture; adding ethanol and propylene glycol to the mixture and mixing nhomogenously to obtain smooth hydrogels; and adding the lyophilized NLC and thoroughly nmixing to obtain nanogels. n12nr(4 (z i00 c r- q n0 0 ~0 r- -n2-co n~0 0 n-a0 CC 0 .0 0 nOa 00 .2 -Z n0= I -0. n0 nE. . n00 n0C 0 n0 CL 0 nwin 0 bb n0. 0w n-w o OD .2 L 0 nnf -c . m .2 nM 0E a -M ot nwL- 0020j n~ n0 0 un .s~~ E! w U20mc n0 ar- nE nLn cra -L m~ n00 0 nr wL 0 ac. n0 a mC 0 nL 22 -P n0 00 n0= 0)0 0L en .2zn nF- .0 0 w n.20 02 wL n-on L 0f 0L on n=0 0 1 0 .2 nona2 0Z5~ non m nt~o M to ' 0 en
priorityDate 2021-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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