| abstract |
The invention discloses a medicine for treating asthma with kidney qi deficiency syndrome, an nanimal model, and a construction and use method. The traditional Chinese medicine ncomponents of the medicine for treating asthma with kidney qi deficiency syndrome are ncomposed of rehmannia glutinosa, cornus, Chinese yam, Alisma, and Sophora flavescens It is ncomposed of 12g each of Tianjiang shell, Moutan bark, Poria, 5g of Schisandra, 8g of nagarwood, Inula, Daimei powder, and 15g of raw astragalus. In the early stage of the present ninvention, a rat model of kidney-qi deficiency asthma combined with syndromes was nestablished, and it was observed that Yishen Chuanning Decoction combined with nglucocorticoids can correct Thl/Th2 imbalance by regulating the expression of transcription nfactors; the present invention takes the specificity of T cell subsets Transcription factors, key ncytokines and microRNAs are indicators to prove the internal mechanism of the onset of nkidney-qi deficiency asthma and the balance of Treg/Th, and reveal the possible multi-target nand multi-level network regulation mechanism of Chinese herbal compound treatment of nasthma.n1/6 nFIGURES n540 clean-grade male Wistar rats, weighing 200-250g; animals were randomly divided into 5101 nnormal control group, asthma model control group, kidney-qi deficiency asthma model ngroup, western medicine group, traditional Chinese medicine group, and combined Chinese nand western medicine group n-S102 nAsthma model: Except for the normal control group, rats in each group were modeled nwith ovalbumin sensitization method nS103 nKidney Qi Deficiency Modeling: Except for the normal control group and the asthma nmodel control group, rats in each group were modeled with compound kidney Qi ndeficiency syndrome nFig. 1 A flowchart of a method for constructing an animal model of asthma and kidney qi ndeficiency provided by an embodiment of the present invention. nFig. 2 A normal group diagram of HE staining results of rat lung tissue provided by an nembodiment of the present invention. |