http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2021100469-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9155441780210ce073407a5a528ec68c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2015-8527 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0622 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6869 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-079 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 2021-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06206e8db6db84e89fada4c5634d6b8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_678a6e7d29368081d9bb004fc90d1034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c5ca03c2de459e3822c9a64913911d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fac2c05cd8222b311e9c24d7036dc6c |
| publicationDate | 2021-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2021100469-A4 |
| titleOfInvention | A Method for Studying the Mechanism of EIF5A2 |
| abstract | The present invention relates to the field of biotechnology. Disclosed is a method nfor studying the mechanism of EIF5A2 in regulating aging, wherein the transcription nfactors BHLHE40 and RHOXF1 are differentially expressed through overexpression nof EIF5A2, thereby regulating the expression of aging-related genes and thus naffecting aging; the transcription factor BHLHE40 is up-regulated and the transcription nfactor RHOXF1 is down-regulated after overexpression of EIF5A2. According to the npresent invention, related transcription factors are differentially expressed through noverexpression of EIF5A2, thereby regulating the expression of aging-related genes nand affecting aging. The present invention lays a solid foundation for the rapid ntranslation of clinical findings into in-depth mechanism studies in cellular models, nanimal models and drug screening under animal model conditions, and provides a ntheoretical basis for the subsequent establishment of EIF5A2 knockout model mice nand the development of therapeutic strategies such as targeted drug development.n1/3 nFIGURES OF THE SPECIFICATION nA B C D nNC LEI tSA2 n1 2z 2 56 sile FLAG 3 Cr s nGAPDHC nEIF5A2_1stn10EIF5A2_2nd 2 nEIFSA2_3rd n3 0 n0996 -8 -6 -4 -2 0 2 4 6 8 n1 40.994 lo9 2 fold change n0.992 nE nCtrl 3rd nE IF EA2_3rd nE IF5EA2_2nd nEIFW li2_st nF EIFSA2 vs Ciri Up GO enrichment P top G EIF5A2 Ctrl Up KEGG pathway G calcium signaling pathway I Iptnme CorrectedP.Value Regulation of action cytoskelton Inputnumber nhornophilic cell adhesion Nicotinate and nictnamide metabolism nCircadian rhythm 2175 nGastric 1aid eretion .200 nInput number Heratopoietic cell lineage CorrectedjP.Value ncell adhesion Pyrimidem oero nB Cholinergic synapse n7I 0Vascular smooth musce contrachon n-log0 Pivalue -log10 Pvalue nEIF5A2 vs Ctrl Down GO enrichment P top EIF5A2vs Cl Down KEGG pathway nactivation of signoin sn r ed oteinpro cengninendopasmicjnunmb ninurooeprtenrspns .nuowe Alcoholism a Input number nendoplasmic reticulm unfolded protein response TNF signalingpathway nprotaolssTNsgalnptha ncelllarproteinmetahbo65 Non-alcoholic fatty liver disease naFLD ntransmemorane transport Corrected PValue Systemic iupus erythematosus * r ed lP.Value positive regulation of cell proliferation • Amphetamine addiction C nregulation of transcription, DNA-dependent .:Thyroid hormonesynthesis ntranscription, DNA-dependent •Caricscl count action n-log0 Pivalue -log10Polue nFig. 1 |
| priorityDate | 2021-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 139.