| abstract |
Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic nanalogs exhibiting affinity for and activity at the neuropeptide S receptor. The molecules may nbe useful in the treatment of disorders, syndromes and conditions mediated by modulation of nthe neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive ndecline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, nschizophrenia and as supportive medication during any kind of cessation program in ncognitive behavioral therapy, such as drug addiction, eating disorders and gambling. |