| abstract |
OF THE DISCLOSURE nProvided is a compound of formula (I) nw nW Ar1-U (i nx nV n(I), nin which Ar', R', U, V, W, X, and p are as described herein. Also provided are methods of nusing a compound of formula (I), including a method of treating cancer, a method of treating na patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate ndehydrogenase A (LDHA) and/ or lactate dehydrogenase B (LDHB) activity in a cell. |