| abstract |
The present disclosure relates to compounds that bind to at least one of ACAT1/2 and nOXCT1/2 and inhibit mitochondrial ATP production, referred to herein as mitoketoscins. Methods nof screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also ndescribed are methods of using mitoketoscins to prevent or treat cancer, bacterial infections, and npathogenic yeast, as well as methods of using mitoketoscins to provide anti-aging benefits. nSpecific mitoketoscin compounds are also disclosed. |