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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39e17306855d2b0f5cb01225cb958893
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publicationDate 2021-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AU-2020207026-A1
titleOfInvention Liposome composition comprising liposomal prodrug of mitomycin C and method of manufacture
abstract A liposome composition comprising a lipophilic prodrug of mitomycin C having an improved pharmacokinetic profile is described. A method for preparing the composition with a solvent system comprised of ethanol and tertiary butanol mixed at an adequate ratio is also described. In an embodiment, the liposome composition is a a population of lipid nanoparticles and a pharmaceutically acceptable vehicle, wherein the population of lipid nanoparticles is comprised of a first fraction of spherical liposomes and a second fraction of rod-shaped lipid nanoparticles, where the second fraction is less than about 15% of the population of lipid nanoparticles.
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