abstract |
Use of a CXCR4 antagonistic peptide and an immune-check point regulator in nthe treatment of cancer is provided. Accordingly there is provided a method of treating ncancer in a subject in need thereof, the method comprising administering to the subject a ntherapeutically effective amount of a peptide having an amino acid sequence as set forth nin SEQ ID NO: 1 or an analog or derivative thereof; and a therapeutically effective namount of a PD1 antagonist, a PDL-1 antagonist, a CTLA-4 antagonist, a LAG-3 nantagonist, a TIM-3 antagonist, a KIR antagonist, an IDO antagonist, an OX40 agonist, na CD137 agonist, a CD27 agonist, a CD40 agonist, a GITR agonist, a CD28 agonist or nan ICOS agonist, thereby treating the cancer in the subject. Also provided are npharmaceutical compositions and articles of manufacture. |