| abstract |
The present invention belongs to the field of organic synthesis, in particular relates to a method for preparing an isoxazoline-containing uracil compound by methylation. The isoxazoline-containing uracil compound shown by formula (I) is prepared by a methylation reaction of a compound shown by formula (II) and monochloromethane in a closed container in the presence of an alkali, a catalyst and an organic solvent, the reaction equation therefor is as follows and the definition of each group in the formula is as in the description. The preparation method provided by the present invention can avoid harm possibly brought by the use of methyl iodide, is safe and environmentally friendly, has a low cost and a high product content, and is suitable for industrialization. |