http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2019326768-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92f3b088742cbcd6faf0b6ec55f9b7d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e19ad3b2bfb8a9a6a21f7c929731e7ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51a9f30761d24e0f14c2324fc56834cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45fdf96a3628013575e9adc0e72e99c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d58fed7fea88d26e500a6817e2de65a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_056c9617d05f1cb60c7c602a4ada0b62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a48a6221448d4a86bf6e59a258704e26 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-81 |
| filingDate | 2019-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6871d6da74b6a774148593dc08348cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae6bfbc62de6524044329414bad57b72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c52fbb7b27331631241814f024437de7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ba72dec31d0338c9e574153f4e9240a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99a8ad59b5a6c57ae5d8bb7b98afb65b |
| publicationDate | 2021-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2019326768-A1 |
| titleOfInvention | 2,6-bis(((1H-benzo[d]imidazol-2-yl)thio)methyl)pyridine and N2,N6-dibenzylpyridine-2,6-dicarboxamide derivatives and related compounds as phosphoinositide 3-kinase (PI3K) inhibitors for treating cancer |
| abstract | 2,6-bis(((lH-benzo[d]imidazol-2-yl)thio)methyl)pyridine and N2, N6-dibenzylpyridine-2, 6-dicarboxamide derivatives and related compounds as phosphoinositide 3-kinase (PI3K) inhibitors for treating cancer. The present invention relates to pharmaceutically active 2,6- bis(((lH-benzo[d]imidazol-2-yl)thio)methyl)pyridine, N2,N6- dibenzylpyridine-2, 6-dicarboxamide and N2,N6-bis(3-hydroxyphenyl) pyridine-2, 6-dicarboxamide, as well as to derivatives thereof, and to structurally related compounds. These compounds are phosphoinositide 3-kinase inhibitors (PI3K) and useful in treating or preventing cancerous diseases. The invention further relates methods of manufacturing such compounds as well as to pharmaceutical compositions and formulations comprising such compounds, optionally together with other pharmaceutically active compounds. The invention further relates to a method for determining the activity of PI3Kalpha or PI3Kalpha mutants, which method includes: a) providing a solid phase which is functionalized by immobilization of GST-GRPl-molecules onto the solid phase, b) performing a PI3Kalpha or PI3Kalpha mutant catalyzed enzyme reaction to convert PIP2 to PIP3, c) adding competitor PIP3 carrying a detectable label or reporter molecule, and d) determining enzyme activity based on the amount of PIP3 obtained in step b) which competes with competitor PIP3 for binding to the functionalized solid phase. |
| priorityDate | 2018-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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