http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2019283981-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_06c87200cf96acdabeae38cd1101927d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2019-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3b3fe8122ee754726b32e0dc7c402d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b70f2a26be1329344e80a19e58fdffb9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3d9439405066c64952335ce456777f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7a6c0a641956cf1a091662b1073e620 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32a00aa5bc13fbe673585302aee1fab7 |
| publicationDate | 2020-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2019283981-A1 |
| titleOfInvention | Analyzing tumor dna in a cellfree sample |
| abstract | Abstract Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance 5 exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based at least in part on the percentage of fetal DNA in a sample, such 10 as maternal plasma, containing a background of maternal nucleic acid sequences. The cutoff value may also be determined based on an average concentration of a sequence per reaction. In one aspect, the cutoff value is determined from a proportion of informative wells that are 15 estimated to contain a particular nucleic acid sequence, where the proportion is determined based on the above mentioned percentage and/or average concentration. The cutoff value may be determined using many different types of methods, such as sequential probability ratio testing 20 (SPRT). 7220306_1 (GHMatters) P83123.AU.5 PETERB 10/12/15 |
| priorityDate | 2007-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 419.