| abstract |
Provided herein are IL-2 muteins, IL-2 mutein Fc-fusion molecules, anti-IL-2 antibodies, and ncomplexes comprising an anti IL-2 antibody bound to an IL-2 cytokine that preferentially expand and nactivate T regulatory cells and are amenable to large scale production. Also provided herein are variant nhuman IgGI Fc molecules lacking or with highly reduced effector function and high stability despite nlacking glycosylation at N297. Also provided herein are linker peptides that are glycosylated when nexpressed in mammalian cells. Also provided herein are methods of making and using the compositions nof the present invention. |