http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2019242628-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_edf0b721898529eb4d8d40a5d20897f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 2019-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47e7ef05b2c71911d8684d5de641a529 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab10a1d557ae2fa708b74f57cb4929ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b6e6b28ce2e48b06d626b2dece38e3e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6a6f3e81c02aa533c5a0b230cc8f3cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8820c8f0e0e6794b5abc0feb7c3732f6 |
| publicationDate | 2020-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2019242628-A1 |
| titleOfInvention | Compositions and methods for inhibiting dihydroorotate dehydrogenase |
| abstract | The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2'-halo-1-1'-biphenyl-4-yl)- quinoline carboxylic acids, which are useful as DHODH inhibitors. |
| priorityDate | 2018-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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