abstract |
: nIsolated human monoclonal antibodies which bind to and inhibit human CD20, and nrelated antibody-based compositions and molecules, are disclosed. The human antibodies ncan be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic nmouse, capable of producing multiple isotypes of human monoclonal antibodies by nundergoing V-D-J recombination and isotype switching. Also disclosed are npharmaceutical compositions comprising the human antibodies, non-human transgenic nanimals and hybridomas which produce the human antibodies, and therapeutic and ndiagnostic methods for using the human antibodies. |