| abstract |
SUSTAINED-RELEASE FORMULATIONS OF COLCHICINE AND METHODS nOF USING SAME nAbstract nPharmaceutical compositions of colchicine for once-a-day oral administration are nprovided. The formulations comprise a sustained-release component and an optional immediatenrelease component, the compositions of which can be selectively adjusted, respectively, to nrelease the active ingredient along a pre-determined or desired release profile. Method of treating nor preventing cardiovascular disease and/or inflammatory disease in mammalian subjects ncomprising the administration of the novel formulations disclosed herein is also provided. |