abstract |
The present invention provides AAV capsid proteins comprising modification of one or a ncombination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the nVP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the npresent invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV ncapsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the npresent invention have improved efficiency in transduction of a variety of cells, tissues and norgans of interest, when compared to wild-type rAAV vectors and virions. |