| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-08 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1892
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-424
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7056 |
| filingDate |
2019-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2020-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e37f4042a87dcf65c296e0c06de3783a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2706b3d5a2b6336955be6fd76958e381
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b67c7c0636934157fa6b8f30d10a949 |
| publicationDate |
2020-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2019200494-B2 |
| titleOfInvention |
Macrolides and methods of their preparation and use |
| abstract |
Provided herein are methods of preparing macrolides by the coupling of an eastern and western nhalf, followed by macrocyclization, to provide macrolides, including both known and novel nmacrolides. Intermediates in the synthesis of macrolides including the eastern and western nhalves are also provided. Pharmaceutical compositions and methods of treating infectious ndiseases and inflammatory conditions using the inventive macrolides are also provided. A ngeneral diastereoselective aldol methodology used in the synthesis of the western half is further nprovided. See Fig. 2.nWO 2014/165792 3/4 PCT/US2014/033025 narylalky) sidechain engages nin stacking and Hbotxing nfour oxyen aoms nface the hydrophfhic tone ni: CS and b12 methy h groups nmake hydrophobic contacts ndesosamine sugar lies in n\0- a cribt ca binding pocket nC241urine akes nhydrphobc cotactC4-ethy s 37 A rom 205 n(a site frequentlkuaedt / nordmehlte yar ehyae nIWFigureF2 |
| priorityDate |
2013-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |