http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018385697-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1266a32eb40f4dd33a2a2efd75c66fd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-545 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate | 2018-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b61abf80cce05b09f9ca43555d304ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34062dd87b6fdd87429ea692b7904535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27aaecdda7499479cd7131cd58e4cf57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14e534886ab990ee64d2cd7fae8b5ee6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7035ef83241de94bc8a7c0cfad977a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d950dbfd91184ad8ea9c13ce3c07a56a |
| publicationDate | 2020-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2018385697-A1 |
| titleOfInvention | Stabilized peptide-mediated targeted protein degradation |
| abstract | The present application describes stapled peptide degron chimeras, which act as protein degradation inducing moieties, either by combining a stapled peptide that binds a disease-related protein with a small molecule degron, such as a cereblon- or VHL-binding small molecule as the degron, or a polypeptide sequence degron, such as a Cop1-binding Trib peptide as the degron; or by combining a stapled peptide degron with a peptide, such as a stapled peptide, or a small molecule that binds a disease-related protein. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of stapled peptide degron chimeras which can be utilized in the treatment of proliferative disorders or other conditions whereby elimination of a disease-causing or disease-related protein would have a therapeutic benefit. The present application also provides methods for making compounds of the application and intermediates thereof. |
| priorityDate | 2017-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 618.