| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e422f44e3db6bd55af90f12e772664fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-454
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-82 |
| filingDate |
2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2022-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e251d5d1a02bb794e22be7ee51d54cc2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b63273309e1202e5480eb4be2c7cf2b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f463b12f7bd255a1729c2a3126edd772
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_314a1e4c07b4264643fba1b1f2671f88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5f529a4e46645a81ac487733e22e066 |
| publicationDate |
2022-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2018288771-B2 |
| titleOfInvention |
Compounds for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| abstract |
Aspects of the present disclosure include methods of reducing the deleterious impact of a target gene in a cell, such as the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a tetrahydrocarbazolamine compound. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided. |
| priorityDate |
2017-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |