http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018286601-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_502d57122688a69ffa7fed51faec87b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec0024795f45a646ef64b3664ab8a26d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate | 2018-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f0028725867af05623651a8db183135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6323d4853acd8fcb9af35999d40b837 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1514f83026ea5432c09de0a70c3d7577 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b6e914d8c1b653cab3bc0bb9ad6d197 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3feec7953a171899e4da2508e537e52a |
| publicationDate | 2019-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2018286601-A1 |
| titleOfInvention | Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy |
| abstract | AMATOXIN-ARMED THERAPEUTIC CELL SURFACE BINDING COMPONENTS DESIGNED FOR TUMOUR THERAPY The invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of a toxin and a target-binding moiety, e.g. an antibody, which are useful in the treatment of cancer. In particular, the toxin is an amatoxin, and the target-binding moiety is preferably directed against tumour-associated antigens. In particular, the amatoxin is conjugated to the antibody by linker moieties. In particular the linker moieties are covalently bound to functional groups located in positions of the amatoxin proved as preferred positions for the attachment of linkers with respect to optimum antitumor activity. In a further aspect the invention relates to pharmaceutical compositions comprising such target-binding moiety toxin conjugates and to the use of such target-binding moiety toxin conjugates for the preparation of such pharmaceutical compositions. The target-binding moiety toxin conjugates and pharmaceutical compositions of the invention are useful for the treatment of cancer. |
| priorityDate | 2009-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 322.