| abstract |
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I): nR 5 nN R nO N R 7 nR3R3b n21 nR nR nH H nH011.- 3 1 n5 6 R4b nR1 R 4a nand pharmaceutically acceptable salts thereof; wherein--, R', R2, R3a, R3 b, R4a ,R R,5 R6 , nand R7are as defined herein. Such compounds are contemplated useful for the prevention and ntreatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, nmood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory nand/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, ntraumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal nsyndromes, and tinnitus. |