abstract |
The present invention is related to a nucleic acid molecule capable of binding to human C5a, nwherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central nstretch of nucleotides comprises a nucleotide sequence of n5'AUGniGGUGKUn2n3RGGGHUGUKGGGn4GnCGACGCA 3' [SEQ ID NO: 61], wherein nni is U or dU, n2 is G or dG, n3 is A or dA, n4 is U or dU, ns is U or dU and nG, A, U, C, H, K, and R are ribonucleotides, and ndU, dG and dA are 2'-deoxyribonucleotides. |