http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018271326-B2

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filingDate 2018-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c22cdac8ed33fe549f35e7757638fc5b
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publicationDate 2021-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AU-2018271326-B2
titleOfInvention Genetically modified major histocompatibility complex mice
abstract The invention provides genetically modified non-human animals that express chimeric nhuman/non-human MHC I and MHC || polypeptides and/or human or humanized p2 nmicroglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also nprovided are constructs for making said genetically modified animals and methods of making nthe same. Methods of using the genetically modified animals to study various aspects of nhuman immune system are provided.
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