Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79fea8edfc865114632d04af9794cf9c |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-22 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8201 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8213 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-01 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
filingDate |
2018-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bb11a4b0a05505cc7bcff69082749d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7366ad45ceaac5908a8851f3caa117a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2c8c3672a2997b40a0c1491865386ad |
publicationDate |
2019-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
AU-2018222092-A1 |
titleOfInvention |
Genome editing system and method |
abstract |
Provided is a genome editing system for site-directed modification of a target sequence in the genome of a cell, which comprises a Cas9 nuclease variant having higher specificity as compared with the wild-type Cas9 nuclease or its expression construct, and an expression construct comprising the coding sequence of tRNA-gRNA fusion or ribozyme-gRNA fusion, or comprises an expression construct comprising the coding sequences of the Cas9 nuclease variant and tRNA-gRNA or ribozyme-gRNA both. Also provided is a method for genetically modifying a cell by introducing the genome editing system, which has high efficiency and high specificity. |
priorityDate |
2017-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |