| abstract |
Abstract Nanoparticles and micro-particles, and pharmaceutical formulations thereof, containing conjugates of an active 5 agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and micro-particles can provide improved temporospatial delivery of the active 10 agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious 15 diseases. 10157337_1 (GHMatters) P104768.AU.1 10/04/18 NCI-H69 xenograft study - 3000 S-9- Vehicle 0 2000 -+ Conjugate 14 2 mg/kg E Conjugate 10 nanopartice, 2 mg/kg >+ DM1, O.8 mg/kg 1- 1000- a 0 -~ 0 10 20 30 40 60 60 70 80 90 100110 Days Dose given |