abstract |
CARBONITRILE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS Abstract The present invention relates to a compound of Formula 1, 2 or 3: R9 R10 R, R1 HO HO Y\ CR R R 3 N R3 n Formula I A4 Formula 2 o z R3 (CR5 R) Formula 3 wherein A is N or -CRo--, where Ro is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is CRe --, or, -N--, where Re is hydrogen, C1-C6 linear or branched chain alkyl,etc.; R1 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1-C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1-C6 linear or branched chain alkyl, etc;. R5and R6 are independently hydrogen or C1-C linear or branched chain alkyl, etc.; R8 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1-C linear or branched chain alkyl, etc.; Q is --CO--, -- (CH2)q--, --(CHRs)q--, or (CRsR)q--, where Rs and R, are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 1, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, for the treatment of certain diseases, particularly those affected or mediated by the androgen receptor; to compbinations comprising such compounds with a second pharmaceutically active ingredient; to compositions containing such combinations; and to such combinations for the treatment of various diseases, particularly, those affected or mediated by the androgen receptor. |