http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018202782-B2

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filingDate 2018-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ef354a013526ab790217f7216293281
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publicationDate 2020-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AU-2018202782-B2
titleOfInvention Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
abstract This invention provides, and in certain specific but non-limiting aspects relates to: n- assays that can be used to predict whether a given ISV will be subject to protein ninterference as described herein and/or give rise to an (aspecific) signal in such an assay n(such as for example in an ADA immunoassay). Such predictive assays could for example nbe used to test whether a given ISV could have a tendency to give rise to such protein ninterference and/or such a signal; to select ISV's that are not or less prone to such protein ninterference or to giving such a signal; as an assay or test that can be used to test whether n10 certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise nto such interference or such a signal; and/or as an assay or test that can be used to guide nmodification or improvement of an ISV so as to reduce its tendency to give rise to such nprotein interference or signal; n- methods for modifying and/or improving ISV's to as to remove or reduce their tendency nto give rise to such protein interference or such a signal; n- modifications that can be introduced into an ISV that remove or reduce its tendency to ngive rise to such protein interference or such a signal; n- ISV's that have been specifically selected (for example, using the assay(s) described nherein) to have no or low(er)/reduced tendency to give rise to such protein interference or n20 such a signal; n- modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise nto such protein interference or such a signal.
priorityDate 2011-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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