| abstract |
H:\sxd\Interwoven\NRPortbl\DCC\SXD\16439647_ .doex-9/02/2018 M "'M R M - N 7Y Compounds of the form in which Q is selected from -COOH -CH=NR W, - CH2NHR 5 -CH=O and -CH(OR 17)2 capable of modulating the activity of histone demethylases (HIDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds. |