| abstract |
The present invention concerns the antiplatelet activity of Acanthus mollis seeds' methanolic extract and the identification of its constituents responsible for this effect, using the techniques LTA, NMR, HPLC and LC-MS, respectively. We have discovered that Acanthus mollis seeds' methanol extract exhibits a double, advantageous antiplatelet activity towards AA- and TRAP-6-induced platelet aggregation, i.e. it specifically inhibits two important pathways leading to platelet aggregation (pathway mediated by TxA |