| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba6ea93e044f6f6f5f994304331cdfb6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-061 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate |
2017-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_304017ecd91b6299ffae6730a2b131d2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17f6f2a81416e0fdc2824c447614a9de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35ad7a29531c0a1419015b9bea0aee80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdb6cbbcdc357630bf349487b6f5c31d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78bb2616d02b0aa453417653e2e3a068
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5b880c00a52e7e7a6416139b1e06f43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a7d7a9cdc3389b008e20a397f3220d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_292dba4e726abd23848e95799a4dc54c |
| publicationDate |
2019-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2017376711-A1 |
| titleOfInvention |
Polymyxin derivative, preparation method and application thereof |
| abstract |
Provided are a polymyxin derivative having a general formula I structure, and a preparation method and an application thereof. The method for preparing the polymyxin derivative comprises the following steps: (1) an Fmoc-AA-OP side chain free amino group of a protected basic amino acid reacting with a halogenated resin to obtain an Fmoc-AA-OP-resin; (2) the Fmoc-AA-OP-resin being coupled one by one to obtain a linear peptide-resin; (3) the linear peptide-resin selectively removing a protective group, and carrying out solid-phase cyclization to obtain a cyclic peptide-resin; (4) the cyclic peptide-resin undergoing acidic hydrolysis and ether precipitation to obtain a crude product of a cyclic polypeptide; (5) the crude product being purified and/or salt transferred and lyophilized to obtain a pure product of the cyclic polypeptide. The polymyxin derivative may be used for preparing an antibacterial drug, and used in particular for preparing an antibacterial drug having an expanded antibacterial spectrum, improved antibacterial activity and reduced renal toxicity, comprising preparing an antibacterial drug against a "super bacteria" which carries the NDM-1 gene. |
| priorityDate |
2016-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |