| abstract |
An anti-CD47 monoclonal antibody and an application thereof. The provided anti-CD47 monoclonal antibody can effectively inhibit tumor growth. Blocking human SIRP and human CD47 signals may enhance macrophage phagocytosis of tumor cells, prevent the tumor cells from escaping a tumor immune defense system, and have an anti-tumor function. Blocking an association between the CD47 on a tumor cell surface and SIRP on a macrophage surface may block a "do not eat me" signal from the tumor cells, promoting macrophage recognition and uptake of the tumor cells, and thereby facilitating tumor cells to be swallowed. The association of the CD47 on a tumor cell surface and SIRP on a macrophage surface is a common "do not eat me" signal. The anti-CD47 antibody, as a very promising target in a tumor immune system, will play a powerful and effective role in human cancer therapy. |