| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_726cc224c76ca555aff94bcef0528b28 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-255
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3264
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-662
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4816
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-69
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C239-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-197
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-27 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-662
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-197
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-48 |
| filingDate |
2017-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80122f472088b555d798fb414a0eacb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba0c114ed685f478e8f3c83f9167971b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_069b319c1d938f2376a73007edcf2ed6 |
| publicationDate |
2019-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2017251704-B2 |
| titleOfInvention |
Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| abstract |
Abstract p-Substituted p-amino acids, p-substituted p-amino acid derivatives, and p-substituted p-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The p-substituted p-amino acid derivatives and p-substituted p-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the P-substituted p-amino acid derivatives and p-substituted p-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The p-substituted p-amino acid derivatives and p-substituted p-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The P-substituted p-amino acid derivatives and p-substituted p-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types. |
| priorityDate |
2014-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |