| abstract |
The invention relates to novel prodrugs or conjugates of the general formula (Ia), in which cytotoxic active agents such as kinesin spindle protein inhibitors, for example, are masked by mean of groups cleavable by legumain, thus releasing the active agent. The invention further relates to the use of said prodrugs or conjugates for treating and/or preventing diseases, and to the use of said prodrugs or conjugates for producing drugs for treating and/or preventing diseases, in particular hyperproliferative and/or angiogenic diseases such as cancers, for example. |